【基本信息】
姓名： 杨立新
职称： 研究员
研究方向： 分子遗传与毒理
【个人履历】
2003/10 – 2007/7，博士，德国海德堡大学（University of Heidelberg, Germany），分子遗传与毒理学；
2000/9 – 2003/03， 硕士，中国科学院遗传与发育生物学研究所，发育生物学；
1985/9 – 1989/7, 学士， 陕西理工大学，生物学。
【工作经历】
2014/4 – 至今，研究员（拟聘），中国环境科学研究院，环境污染与健康创新研究基地；
2009/10 - 2013/9， 项目研究组长（research scientist and project group leader），德国卡尔斯鲁厄理工大学 (KIT, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics)；
2007/8 - 2009/9， 博士后，德国卡尔斯鲁厄理工大学（KIT ) 毒理与遗传研究所；
1989/8 - 2000/9， 助教、讲师，陕西理工大学生命科学与技术学院。
【科学研究】
研究领域与主要研究方向
主要从事毒理基因组学、化学物质毒性效应高通量评价方法和技术、神经细胞发育调控机理研究。
【社会工作】
欧洲鱼类生物医学学会会员（EuFishBioMed, European Society for Zebrafish Models in Biology and Medicine）;
【荣誉奖励】
2007年荣获德国亥姆霍兹卡尔斯鲁厄国家研究中心优秀研究成果。
【其他】
培养博士、硕士研究生各2名。
主要论文论着
1. Lixin Yang#, Xiang-Yu Hou, Yongjie Wei, Phong Thai, Fahe Chai. Biomarkers of the health outcomes associated with ambient particulate matter exposure. Science of The Total Environment, 2017,579,1446-1459( # Corresponding author).
2. Maryam Shahid, Masanari Takamiya, Johannes Stegmaier, Volker Middel, Marion Gradl, Nils Klüver, Ralf Mikut, Thomas Dickmeis, Stefan Scholz, Sepand Rastegar, Lixin Yang# & Uwe Strähle. Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports, 2016, 6:23768/DOI: 10.1038/srep23768 ( # Corresponding author).
3. Marco Ferg, Olivier Armant, Lixin Yang, Thomas Dickmeis, Sepand Rastegar and Uwe Strähle. Gene transcription in the zebrafish embryo: Regulators and networks. Briefings in Functional genomics, 2014 Mar;13(2):131-43.
4. Johannes Stegmaier, Maryam Shahid, Masanari Takamiya, Lixin Yang, Sepand Rastegar, Markus Reischl, Uwe Strähle, and Ralf Mikut. Automated Prior Knowledge-Based Quantification of Neuronal Patterns in the Spinal Cord of Zebrafish. Bioinformatics, 2014 Mar 1;30(5):726-33.
5. Nga Yu Ho#, Lixin Yang#, Jassica Legradi, Olivier Armant, Masanari Takamiya, Sepand Rastegar and Uwe Strähle. Gene Responses in the Central Nervous System of Zebrafish Embryos Exposed to the Neurotoxicant Methyl Mercury. Environmental Science &Technology, 2013, 47, 3316-3325.
6. Olivier Armant, Martin März, Rebecca Schmidt, Marco Ferg, Nicolas Diotel, Raymond Ertzer, Jan Christian Bryne, Lixin Yang, Isabelle Baader, Markus Reischl, Jessica Legradi, Ralf Mikut, Derek Stemple, Wilfred van IJcken, Antoine van der Sloot, Boris Lenhard, Sepand Rastegar and Uwe Strähle. Genome-wide analysis of transcriptional regulators in zebrafish embryos. Developmental Biology, 2013, 380, 351-362.
7. Lixin Yang, Sepand Rastegar and Uwe Strähle. Regulatory interactions specifying Kolmer-Agduhr interneurons. Development, 2010, 137(16), 2713-2722.
8. Lixin Yang, Nga Yu Ho, Ferenc Müller and Uwe Strähle. Methyl mercury suppresses the formation of the tail primordium in developing zebrafish embryos. Toxicological Sciences, 2010, 115(2), 379-390.
9. Markus Wahl, Rene Guenther, Lixin Yang, Ake Bergman, Uwe Straehle, Siegfried Strack, Carsten Weiss. Polybrominated diphenyl ethers and arylhydrocarbon receptor agonist different toxicity and target gene expression. Toxicology Letters, 2010, 198(2):119-126.
10. Lixin Yang, Nga Yu Ho, Rüdiger Alshut, Jessica Legradi, CarstenWeiss, Markus Reischl,Ralf Mikut, Urban Liebel, Ferenc Müller, Uwe Strähle. Zebrafish embryos as models for embryotoxic and teratological effects of chemicals. Reproductive Toxicology, 2009, 245–253.
11. Marco Ferg, Remo Sanges, Jochen Gehrig, Janos Kiss, Matthias Bauer, Agnes Lovas,Monika Szabo, Lixin Yang, Uwe Straehle, Michael J Pankratz, Ferenc Olasz, Elia Stupka and Ferenc Muller. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. The EMBO Journal, 2007, 26, 3945–3956.
12. Lixin Yang, Jules R Kemadjou, Christian Zinsmeister, Matthias Bauer,Jessica Legradi, Ferenc Müller, Michael Pankratz, Jens Jäkel and Uwe Strähle. Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo. Genome Biology, 2007, 8:R227.
